General immunodeficiency & recurrent infections

Micronutrient therapy

Micronutrients for immune stimulation
Zinc studies show a direct influence on the risk of disease and the duration and intensity of disease. A deficient zinc supply impairs in particular the formation and activity of phagocytes and natural killer cells. It is also suspected that zinc inhibits the formation of inflammatory cytokines and thus has a direct influence on the infection process (daily dose 60-90 mg).

In colds, timely and sufficiently high vitamin C supplementation (1-5 g/d) can significantly reduce the duration of the disease in adults and children. High doses of vitamin C can prevent a drop in the vitamin C concentration in the leukocytes and thus increase their phagocytosis activity.
Supported by bovine antibodies
Bovine colostrum is almost identical to human colostrum. This first milk is characterized by special ingredients, including immunoglobulins (IgG, IgA, IgM), glycoproteins such as lactoferrin and proline-rich polypeptides (PRP), whose spectrum of action lies primarily in broad-spectrum immunomodulation.
Immunostimulation with “biological response modifiers”
Beta-Glucan is a natural polysaccharide which docks to the beta-1,3/1,6-glucan molecule-specific receptor site of the macrophage and thus activates and strengthens it. In addition, a specific defense mechanism is triggered by messenger substances. In addition, beta-glucan suppresses the formation of superoxide anions and hydrogen peroxide, which can weaken the immune cells through their effect as free radicals. An improvement in the activity of the natural and lymphokine-activated killer cells has also been demontrated.

In addition to the extraction of beta-glucan from yeast cells, the medicinal fungi Reishi and Shiitake are frequently used in TCM natural sources of beta-glucan in TCM. Shiitake contains Lentinian, a bioactive beta-glucan fraction. It improves the release of immunoglobulin IgA on mucosal surfaces, increases the formation of monocyte-specific T cells and intensifies the cytotoxic effect of macrophages against bacteria and viruses. In addition, special antibodies are formed (IgG2 and IgM heterophilic antibodies), which can build up an additional specific immunological protection. Reishi contains a special proteoglycan, GLIS, which activates the B-lymphocytes. Studies have shown a stimulation of immune cell formation in the spleen and an influence of Reishi spores on the formation of immune-relevant tissue hormones.

The fungus Coriolus contains the two protein-bound polysaccharides PSP and PSK as primary biological components. Additionally, tumor-inhibiting and antiviral effects have also been described in studies on Coriolus.
 Traditional plant extracts to strengthen the immune system

Plant extracts can influence the performance of the human immune system via various mechanisms. There are immune stimulants which promote the activities of the non-specific immune system and additionally, many plant substances have a direct antibacterial and antiviral effect against antigens.

Cat’s Claw (Uncaria tomentosa) is a liana species whose root extract is traditionally used in South American herbal medicine for chronic inflammations, infections, tumurs and stomach ulcers.

Astragalus membranaceus is an important medicinal herb in Chinese medicine. Specific polysaccharide fractions, which can activate both macrophages and B cells, appear to be responsible for the proven immunostimulatory effects. In addition, it regulates the proliferation of monocytes, improves the effect of T lymphocytes on tumor cells by specifically promoting phagocytosis activity and increases cytokine production (TNF-alpha and IL-6). In addition to the positive effects on the immune system, Astragalus membanaceus also appears to be suitable for adjuvant use in chemotherapy. As a complementary accompanying therapeutic agent, it increases the effectiveness of chemotherapy and presumably reduces the toxic side effects.

Neem (Azadirachta indica) belongs to the phytotherapeutics of Indian culture with strong antibacterial properties. Certain components of the plant inhibit the ability of bacteria to multiply by interfering with the construction of bacterial membranes. The extract also appears to be active against some bacterial strains that have already developed antibiotic resistance. Antiviral properties, especially in retroviruses, have also been proven. The essential oil contained in eucalyptus has a strong expectorant and anti-inflammatory effect and serves to strengthen the immune system. The immune-boosting and antimicrobial effect of eucalyptus of oil have been confirmed by numerous studies.

The South African medicinal plant Pelargonium sidoides is used in the treatment of colds, especially bronchitis, due it is antbacterial, antiviral and immune-modulating properties. 

Phyllantus emblica, also known as Indien gooseberry or amla, is one of the best studied medicinal plants and is said to have antibacterial, fungidcidal, antiviral, antidiabetic, antioxidant, anti-inflammatory, immune-modulating, analgesic, antiatherogenic and antipathogenic properties, among others. The many minerals and amino acids and the high content of vitamin C as well as whole range of phenolic compounds such as tannins, phyllemblin, rutin and curcuminoids are responsible for these effects. 

Diagnostic tests

Available laboratory tests (Laboratory GANZIMMUN) Detailed information
Lymphocytes Differentiation of the lymphocyte subpopulations Cellular Immunology

NK cell activity

Tumor Killing Test

Sensitive marker to detect cellular immune activation NK cell activity
Interferon-gamma induced protein 10 Sensitive marker to detect cellular immune activation IP-10
Lymphocyte function Assessment of the immunological memory function 3HT-Memory-Spot 
Allergo-Screen® Inhalation (IgE) detection of inhalation allergies considering the 36 most important allergens Allergo-Screen® Concept
Florastatus Detection of a disturbed intestinal flora Florastatus
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