Micronutrient therapy
| reduce nitrostress | |
| The use of high-dose antioxidants such as vitamin E, vitamin C and alpha-lipoic acid has proven effective for the dietary treatment of nitrosative stress states. An important NO scavenger is Vitamin B12, which is able to reduce high NO concentrations in certain diseases. Oxidation of NO causes vitamin B12 to be withdrawn from the metabolism during nitrosative stress, which is why a vitamin B12 deficiency can often be observed in affected patients. Also folic acid and vitamin B6 as well as further B-vitamins are needed in the citrate cycle. Another effective adjuvant for the treatment of nitrosative stress states is curcumin . As an active peroxinitrite scavenger it stimulates the formation of reducing glutathione. This enables curcumin to regulate the NO/ONOO mechanism during nitrosative stress. Taurine can make an important contribution to the interruption of nitrosative stress. |
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| Respiratory chain support | |
| Coenzyme Q10 plays a key role in cellular energy production and is a central antioxidant in cells. In energy generation, coenzyme Q10 provides the electrons required in the mitochondrial respiratory chain for ATP synthesis. The highest coenzyme Q10 concentrations are therefore also found in organs with high energy requirements such as the heart muscle, liver, kidneys and pancreas. More than 90 % of the coenzyme Q10 is present in the active reduced ubiquinol form. As a redox partner, ubiquinol is involved in antioxidative processes in the cytosol, the golgi apparatus, the lyosomes and the plasma membrane and regenerates vitamin E radicals in particular. Through its role in the antioxidative protection of biological membranes, coenzyme Q10 contributes to a strengthening of the immune defence, promotes the integrity and stabilisation of cell membranes and prevents radical-induced ageing processes of the cell organs. L-Carnitine is mainly formed in the skeletal muscles and in the heart muscle, where it is involved in the oxidative degradation of long-chain fatty acids and the resulting release of energy. The L-carnitine acts as a transport molecule that transports the activated fatty acids into the mitochondria, where the β oxidation takes place. L-carnitine is thus a decisive factor for energy supply and physical performance. |