MikronährstoffCoach®: Mikronährstoffe / mikronaehrstoffcoach.com

Sources and physiological effects

Dietary sources
Hyaluronic acid is an important component of connective tissue and cartilage. Hyaluronic acid is always present in food in combination with glucosamine glycans and collagen, e.g. in rooster combs.
Physiological effects
Connective tissue	Important component of connective tissue, such as skin
Cartilage	The formation of proteoglycans contributes to the pressure resistance of cartilage
Joints	As the main component of the synovia, responsible for physiological gliding in all joint movements .

Recommended intake

Nutrient safetys
Hyal-Joint^® has GRAS-Status in USA (generally recognized as safe)

Detailed information

Hyal-Joint^®-Hyaluronic acid

The quality of a raw material and thus of a complete preparation can decisively influence the success of a therapy. Raw materials are available on the world market, in some cases in very different qualities. Cheap preparations may contain ineffective, contaminated or unsafe ingredients. The demand of therapists and patients for trustworthy, traceable and clinically tested raw materials (1) led to the development of high-quality raw materials pharmaceutical grade.
CS BioActive^®Hyal-Joint^® is a European high-quality raw material from Bioibérica. Bioiberica has been intensively involved in cartilage research for many years and is one of the world's leading producers in this segment thanks to decades of experience.

Hyal-Joint^® - first-class effectiveness in the complementary arthrosis therapy

The therapeutic efficacy of Hyal-Joint^® has neem confirmed in numerous studies, including 2 clinical trials. Hyal-Joint^® is an active complex that contains hyaluronates and special glycosamine glycans. Synergistic effects make Hyal-Joint^® 2-4 times more effective compared to pure hyaluronic acid in terms of improving synovial fluid (concentration and viscosity) and stimulating hyaluronic self-synthesis.
In clinical studies, the subjects reported an improvement in joint mobility in activities such as climbing stairs or walking after just 8 weeks. The pain relief also led to an improvement in emotional well-being (2). These observations were accompanied by a significant improvement in synovial fluid(3).

Dermial^®- Active complex to improve the dermal moisture content

A decrease in hyaluronic acid concentration in the dermis is seen as a cause for the loss of moisture, resilience and elasticity of the skin. Hyaluronic acid has an enormously high water-binding capacity. As a component of the extracellular matrix in which the collagen and elastic fibers are embedded in the connective tissue, it stimulates the formation of collagen and elastin. It also supports the supply of nutrients to the skin. In addition to the increase in skin thickness, studies also point to cytoprotective effects of hyaluronic acid and its fragments after UV exposure due to its ability to reduce oxidative stress (4).

The high-quality raw material Dermial ^®, a hyaluronic acid-glucosamine complex from the Spanish quality manufacturer Bioibérica, supplies the skin with the two nutrients hyaluronic acid and glucosamine and its derivative N-acetyl-glucosamine. These are amino sugars which serve as precursors for the biosynthesis of certain polymers such as glycosaminoglycans (e.g. hyaluronic acid) and proteoglycans. Several positive effects on the skin and skin cells have been documented for glucosamine compounds. By stimulating hyaluronic acid synthesis, glucosamine accelerates wound healing, reduces wrinkles and improves the moisture content of the skin. It also inhibits melanin formation by inhibiting tyrosinase activity and is a useful adjuvant therapy in hyperpigmentation (5).

Cell studies with the raw material Dermial ^® show that the hyaluronic acid-glucosamine complex increases the intracellular hyaluronic acid concentration and can thus give the cells more moisture (6).

Reference values

Parameter	Substrate	Reference value	Description
COMP	Blood (serum)	< 12.0 U/l	< 12.0 U/l: low risk of aggressive joint destruction 12-15 U/l: Increasing risk of aggressive joint destruction > 15 U/l: high risk of aggressive joint destruction

Indications

Effect	Indication	Dosage
Physiological effects at a low intake	For degenerative and/or inflammatory joint diseases such as osteoarthritis or osteochondritis	50 - 100 mg/d
	To maintain and rebuild cartilage structures and improve joint function in degenerative joint diseases	50 - 100 mg/d
	Preventive therapy to preserve cartilage tissue and joint functions under stress and in high-performance athletes	50 - 100 mg/d
	For nutritive support of the skin and skin structure, especially for reduced skin tone and reduced water binding capacity	50 - 100 mg/d

Administration

General mode of administration
When	Hyaluronic acid should be taken between meals.
Side effects
No side effects are known to date.
Contraindications
No contraindications are known to date.

Interactions

Drug interactions
None	No interactions are known to date.
Nutrient interactions
None	No interactions are known to date.

Description and related substances

Description

Hyaluronic acid is an endogenous glycosamine glycan.

Related substances

The oral uptake depends on the molar mass. Hyaluronic acid with > 1000 kDa (a relatively high molar mass) has proven an oral bioavailability in studies, hyaluronic acid with a lower molar mass is poorly bioavailable.

References

1) Volpi, N. 2009. Quality of different chondroitin sulfate preparations in relation to their therapeutic activity. Pharmacol. 61(10):1271-80.2) Bioibérica. 2003. Study on the chondroprotective Effects of Hyal- Joint®.
3) Bioibérica. 2005. Study of the difference between Hyal-Joint® and hyaluronic acid on synovial fluid. La Coruna.
4) Stauber, G. 2009. Dermokosmetische Prävention vorzeitiger Hautalterung. medicos
5) Bissett, D. L. 2006. Glucosamine: an ingredient with skin and other benefits. J Cosmet Dermatol. 5(4):309-15.
6) Bioibérica. Study of dermial® on the synthesis of endogenous hyaluronic acid.
7) Bioibérica. Study of the protective effect of dermial® against the breakdown of collagen.
8) Shibata, K. Tsubouchi, R. 2008. Clinical effects of N-acetylglucosamine supplementation on dry skin. Aestetic Dermatol. 18:91-99.

References Interactions:
Stargrove, M. B. et al. Herb, Nutrient and Drug Interactions: Clinical Implications and Therapeutic Strategies, 1. Auflage. St. Louis, Missouri: Elsevier Health Sciences, 2008.
Gröber, U. Mikronährstoffe: Metabolic Tuning –Prävention –Therapie, 3. Auflage. Stuttgart: WVG Wissenschaftliche Verlagsgesellschaft Stuttgart, 2011.
Gröber, U. Arzneimittel und Mikronährstoffe: Medikationsorientierte Supplementierung, 3. aktualisierte und erweiterte Auflage. Stuttgart: WVG Wissenschaftliche Verlagsgesellschaft Stuttgart, 2014.